Primordial information content of Rayleigh anisotropies

Anisotropies in the cosmic microwave background (CMB) are primarily generated by Thomson scattering of photons by free electrons. Around recombination, the Thomson scattering probability quickly diminishes as the free electrons combine with protons to form neutral hydrogen off which CMB photons can scatter through Rayleigh scattering. Unlike Thomson scattering, Rayleigh scattering is frequency dependent resulting in the generation of anisotropies with a different spectral dependence. Unfortunately the Rayleigh scattering efficiency rapidly decreases with the expansion of the neutral universe, with the result that only a small percentage of photons are scattered by neutral hydrogen. Although the effect is very small, future CMB missions with higher sensitivity and improved frequency coverage are poised to measure Rayleigh scattering signal. The uncorrelated component of the Rayleigh anisotropies contains unique information on the primordial perturbations that could potentially be leveraged to expand our knowledge of the early universe. In this paper we explore whether measurements of Rayleigh scattering anisotropies can be used to constrain primordial non-Gaussianity (NG) and examine the hints of anomalies found by WMAP and \textit{Planck} satellites. We show that the additional Rayleigh information has the potential to improve primordial NG constraints by $30\%$, or more. Primordial bispectra that are not of the local type benefit the most from these additional scatterings, which we attribute to the different scale dependence of the Rayleigh anisotropies. Unfortunately this different scaling means that Rayleigh measurements can not be used to constrain anomalies or features on large scales. On the other hand, anomalies that may persist to smaller scales, such as the potential power asymmetry seen in WMAP and \textit{Planck}, could be improved by the addition of Rayleigh measurements.Comment: 12 pages, 5 figure

Game design in an Internet of Things

Whilst no consensus yet exists on how the Internet of Things will be realised, a global infrastructure of networked physical objects that are readable, recognizable, locatable, addressable and controllable is undoubtedly a compelling vision. Although many implementations of the Internet of Things have presented these objects in a largely ambient sensing role, or providing some form of remote access/control, in this paper we consider the emerging convergence between games and the Internet of Things. This can be seen in a growing number of games that use objects as physical game pieces to enhance the players’ interaction with virtual games. These hybrid physical/digital objects present game designers with number of interesting challenges as they i) blur the boundaries between toys and games; ii) provide opportunities for freeform physical play outside the virtual game; and iii) create new requirements for interaction design, in that they utilise design techniques from both product design and computer interface design. Whilst in the past the manufacturing costs of such game objects would preclude their use within games from small independent games developers, the advent of low cost 3D printing and open software and hardware platforms, which are the enablers of the Internet of Things, means this is no longer the case. However, in order to maximise this opportunity game designers will need to develop new approaches to the design of their games and in this paper we highlight the design sensibilities required if they are to combine the digital and physical affordances within the design of such objects to produce good player experiences

Fundamental limits on constraining primordial non-Gaussianity

Theoretical Physic

Multi-analyte profiling and pathway analysis of plasma for proteins associated with cancer-related fatigue syndrome in disease-free breast cancer patients after primary treatment.

CONTEXT: A significant number of women treated for breast cancer develop long-term fatigue afterwards. Previous research has suggested that fatigue may be due to a prolonged inflammatory response. However, there are conflicting results and the exact nature of the disturbance remains unclear. OBJECTIVES: To identify inflammatory markers associated with fatigue. METHODS: We recruited women from a breast cancer follow-up clinic and categorised them on the basis of a diagnostic interview as to whether they met the criteria for cancer-related fatigue syndrome (cases) or not (controls). We took plasma samples from each participant to analyse subsequently using a panel of 88 biological markers. RESULTS: 90 samples were analysed in total (45 cases and 45 controls). A factorial analysis of variance (using age as a fixed factor) demonstrated a number of differences in inflammatory cytokines. There were 28 significantly different analytes in total. Granulocyte colony stimulating factor was the most significantly different analyte (p<0.001). Many of the significant analytes were chemokine ligands found to be linked through an inflammatory pathway promoting T-cell and granulocyte production and activation. CONCLUSIONS: Our results add further weight to the hypothesis that cancer-related fatigue syndrome is associated with an increased pro-inflammatory immune response. Our findings indicate that these cytokine changes could underpin the subjective symptoms, such as perceived muscle weakness and concentration difficulties, experienced by women who feel fatigued after treatment

A Socio-Spatial Approach to Enable Inclusive Well-Being in Cities: A Case Study of Birmingham, UK

This article examines density and deprivation, the two important parameters that define health and well-being in cities. Discussions are drawn from a case study conducted in Birmingham in four neighborhoods characterized by their different population density and deprivation levels. Data were collected through questionnaires developed from a set of subjective well-being measures and built environment audits, based on the Irvine Minnesota Inventory that evaluates the quality of streets and walkability in neighborhoods. The inferences from the study support the need for linking health, planning, policy and design research and decision-making to the socio-spatial practices of people, impacting well-being at the everyday level. The findings provide a holistic approach health and well-being research and suggests a conceptual framework for inclusive well-being in cities, which signifies the role of social and spatial parameters in determining peoples’ health and well-being. The study also highlights the lack of interdisciplinary research in understanding the association between well-being and social and behavioral practices in diverse communities

Formins Determine the Functional Properties of Actin Filaments in Yeast

The actin cytoskeleton executes a broad range of essential functions within a living cell. The dynamic nature of the actin polymer is modulated to facilitate specific cellular processes at discrete locations by actin-binding proteins (ABPs), including the formins and tropomyosins (Tms). Formins nucleate actin polymers, while Tms are conserved dimeric proteins that form polymers along the length of actin filaments. Cells possess different Tm isoforms, each capable of differentially regulating the dynamic and func- tional properties of the actin polymer. However, the mecha- nism by which a particular Tm localizes to a specific actin polymer is unknown. Here we show that specific formin family members dictate which Tm isoform will associate with a particular actin filament to modulate its dynamic and functional properties at specific cellular locations. Exchanging the localization of the fission yeast formins For3 and Cdc12 results in an exchange in localizations of Tm forms on actin polymers. This nucleator-driven switch in filament composition is reflected in a switch in actin dynamics, together with a corresponding change in the filament’s ability to regulate ABPs and myosin motor activity. These data establish a role for formins in dictating which specific Tm variant will associate with a growing actin filament and therefore specify the functional capacity of the actin filaments that they create

Ghosts in the Smart Home

We are in the midst of a ‘post-anthropocentric’ turn in design, research and technology. The term refers to a renewed interest in a wide range of concepts, theoretical perspectives, and methodologies. Ghosts in the Smart Home is a post-anthropocentric experiment which manifests as a film whose cast of characters are all internet connected ‘smart’ devices. The motivation is to prototype and establish new ways to see, to be, and to know, which respond to the 21st century’s complex socio-technical system

What makes people stay in or leave shrinking cities? An empirical study from Portugal

The attractiveness of cities as places to live determines population movements into or out of them. Understanding the appealing features is fundamental to local governments, particularly for cities facing population decline. Pull and push attributes can include economic aspects, the availability of amenities and psychological constructs, initiating a discussion around which factors are more relevant for migration. However, such discussion has been underexplored in studies of shrinking cities. In the present study, we contribute to the discussion by identifying pull and push factors in Portuguese shrinking cities. Data were collected using a face-to-face questionnaire of 701 residents in four shrinking cities: Oporto, Barreiro, Peso da Regua and Moura. Factor analysis and automatic linear modelling were used to analyse the data. Our results show that the economic activity is the most relevant feature for retaining residents. However, characteristics specific to each city, related to heritage and natural beauty, are also shown to influence a city's attractiveness. The cause of population shrinkage was also found to influence residents' assessments of the pull and push attributes of each city. Furthermore, the results show the relevance of social ties and of place attachment to inhabitants' intention to continue living in their city of residence

Minimizing gravitational lensing contributions to the primordial bispectrum covariance

The next generation of ground-based cosmic microwave background (CMB) experiments aim to measure temperature and polarization fluctuations up to ℓmax≈5000 over half of the sky. Combined with Planck data on large scales, this will provide improved constraints on primordial non-Gaussianity. However, the impressive resolution of these experiments will come at a price. Besides signal confusion from galactic foregrounds, extragalactic foregrounds, and late-time gravitational effects, gravitational lensing will introduce large non-Gaussianity that can become the leading contribution to the bispectrum covariance through the connected four-point function. Here, we compute this effect analytically for the first time on the full sky for both temperature and polarization. We compare our analytical results with those obtained directly from map-based simulations of the CMB sky for several levels of instrumental noise. Of the standard shapes considered in the literature, the local shape is most affected, resulting in a 35% increase of the estimator standard deviation for an experiment such as the Simons Observatory (SO) and a 110% increase for a cosmic-variance limited experiment, including both temperature and polarization modes up to ℓmax=3800. Because of the nature of the lensing four-point function, the impact on other shapes is reduced while still non-negligible for the orthogonal shape. Two possible avenues to reduce the non-Gaussian contribution to the covariance are proposed: First by marginalizing over lensing contributions, such as the Integrated Sachs Wolfe (ISW)-lensing three-point function in temperature, and second by delensing the CMB. We show the latter method can remove almost all extra covariance, reducing the effect to below <5% for local bispectra. At the same time, delensing would remove signal biases from secondaries induced by lensing, such as ISW lensing. We aim to apply both techniques directly to the forthcoming SO data when searching for primordial non-Gaussianity